Document Details
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Document Type |
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Thesis |
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Document Title |
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Response of liver and heart functions to L-carnitine intake in a model of nonalcoholic fatty liver disease in rats إستجابة وظائف الكبد والقلب لتناول ل_كارنتين في نموذج لمرض تشحم الكبد اللا كحولى المحدث بالجرذان |
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Document Language |
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Arabic |
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Abstract |
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It is well known that the development of non-alcoholic fatty liver disease (NAFLD) is related to obesity, type 2 diabetes mellitus (T2DM), hyperlipidemia and hypertension. The improvement of socio-economical status in Saudi Arabia, resulted in change in dietary habit and the substantial increase in dietary fructose consumption that has recently been linked with increased risk for weight gain, type 2 diabetes or NAFLD. Thus the progress in knowledge of NAFLD will not only benefit the health status of Saudi people, but also push forward our recognition of the whole diseases of metabolism disturbance including T2DM. Therefore, the present study investigated the effect of high fructose consumption on the development of NAFLD through studying the change of biochemical parameters in rats and the possible role of L-carnitine consumption in amelioration these changes. Forty adult male Wistar rats were divided into four groups (10 rats each group); group one served as control, group two recived doses of l-carnitine (3.75 mg/kg/day) by gavage in the last two weeks, group three recived high fructose diet (HFD) (10% fructose in drinking water) that were administered for 6 weeks and group four received HFD and doses of l-carnitine (3.75 mg/kg/day) by gavage in the last two weeks. The results showed that animals fed with fructose increased in serum glucose, insulin, insulin resistance, lipid profile indices (cholesterol, TG and LDL), cardiovascular biomarkers such as (CK and CK-MP), lipid peroxidation; a marker of oxidation stress; and pro-inflammatory cytokines (VEGF, CRP and IL-6) levels. While adminstrating L-carnitine orally resulted in a significant decrease in glucose, level of insulin resistance, LDL, CK, CK-MP, VEGF, CRP and IL-6 levels. The conclusion of this study confirmed the beneficial effect of L-carnitine on NAFLD |
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Supervisor |
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Mohamed Elshal |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1431 AH
2010 AD |
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Number Of Pages |
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104 |
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Co-Supervisor |
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Sawsan khoja |
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Added Date |
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Wednesday, November 19, 2014 |
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Researchers
| البتول عبدالعزيز رديني | Redainy, Al-batul Abdulaziz | Investigator | Master | |
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